Publications

Researchers and physicians at the Center for Clincal Cancer Genetics have publised numerous scientific articles on findings discovered since the center was created.  Listed below is a sampling of some of our most recent publications:

2017

Chiyoda T, Hart PC, Eckert MA, McGregor SM, Lastra RR, Hamamoto R, Nakamura Y, Yamada SD, Olopade OI, Lengyel E, Romero IL. Loss of BRCA1 in the cells of origin of ovarian cancer induces glycolysis: A window of opportunity for ovarian cancer chemoprevention. Cancer Prev Res (Phila) 2017.

Guidugli L, Knight Johnson A, Alkorta-Aranburu G, Nelakuditi V, Arndt K, Churpek JE, Godley LA, Townsley D, Young NS, Fitzpatrick C, Das S, del Gaudio D, and Li Z.  Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes.  Leukemia.  2017 Jan 20.

Huo, Dezheng, et al. "Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas." JAMA Oncology (2017).

Stier M, Stoll J, Kupfer SS. A Diagnosis of Small Bowel Polyposis. Gastroenterology. 2017; 152: e9-e10.

2016

Catucci I, Casadei S, Ding YC, Volorio S, Ficarazzi F, Falanga A, Marchetti M, Tondini C, Franchi M, Adamson A, Mandell J, Walsh T, Olopade OI, Manoukian S, Radice P, Ricker C, Weitzel J, King MC, Peterlongo P, Neuhausen SL.  "Haplotype analyses of the c.1027C>T and c.2167_2168delAT recurrent truncating mutations in the breast cancer-predisposing gene PALB2."  Breast Cancer Res Treat (2016).

Churpek JE, Marquez R, Claussen K, Neistadt B, Lee MK, Churpek MM, Huo D, Weiner H, Bannerjee M, Godley LA, Le Beau MM, Pritchard CC, Walsh T, King M-C, Olopade OI, and Larson RA.  Inherited mutations in cancer susceptibility genes are common among breast cancer survivors who develop therapy-related leukemia.  Cancer.  2016 Jan 15;122(2):304-11.  PMID: 26641009. 

Dunning, A. M., K. Michailidou, K. B. Kuchenbaecker, D. Thompson, J. D. French, J. Beesley, C. S. Healey, et al. "Breast Cancer Risk Variants at 6q25 Display Different Phenotype Associations and Regulate Esr1, Rmnd1 and Ccdc170." Nat Genet 48, no. 4 (Apr 2016): 374-86.

Ezewuiro, Obiageli, Tatyana A. Grushko, Masha Kocherginsky, Mohammed Habis, Jean A. Hurteau, Kathryn A. Mills, Jessica Hunn, Olufunmilayo I. Olopade, Gini F. Fleming, and Iris L. Romero. "Association of Metformin Use with Outcomes in Advanced Endometrial Cancer Treated with Chemotherapy." PLoS One 11, no. 1 (2016).

Guindalini RS, Song A, Fackenthal JD, Olopade OI, Huo D. Genetic anticipation in BRCA1/BRCA2 families after controlling for ascertainment bias and cohort effect. Cancer 2016; 122: 1913-1920.

 Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D’Andrea RJ, Lewis IA, Medeiros BC, Pollyea DA, King M-C, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, and Scott HS.  Novel germline DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.  Blood. 2016 Feb 25;127(8):1017-23.  PMID: 26712909.   These authors contributed equally to this work.

Huo D, Feng Y, Haddad S, Zheng Y, Yao S, Han YJ, Ogundiran TO, Adebamowo C, Ojengbede O, Falusi AG, Zheng W, Blot W, Cai Q, Signorello L, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Nathanson KL, Domchek SM, Rebbeck TR, Ruiz-Narváez EA, Sucheston-Campbell LE, Bensen JT, Simon MS, Hennis A, Nemesure B, Leske MC, Ambs S, Chen LS, Qian F, Gamazon ER, Lunetta KL, Cox NJ, Chanock SJ, Kolonel LN, Olshan AF, Ambrosone CB, Olopade OI, Palmer JR, Haiman CA.  "Genome-wide Association Studies in Women of African Ancestry Identified 3q26.21 as a Novel Susceptibility Locus for Estrogen Receptor Negative Breast Cancer."  Hum Mol Genet (2016): ddw305.

Mathias, Rasika Ann, Margaret A. Taub, Christopher R. Gignoux, Wenqing Fu, Shaila Musharoff, Timothy D. O'Connor, Candelaria Vergara et al. "A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome." Nature communications 7 (2016): 12522.  

McKillip RP, Hahn OM, Sulai NH, Olopade OI, Arora VM, Golden DW.  "Introducing Medical Students to Radiation Oncology Through an Elective Oncology Summer Program."  Int J Radiat Oncol Biol Phys (2016); 96(2S):E413.  doi: 10.1016/j.ijrobp.2016.06.1669.

Meeks, H. D., H. Song, K. Michailidou, M. K. Bolla, J. Dennis, Q. Wang, D. Barrowdale, et al. "Brca2 Polymorphic Stop Codon K3326x and the Risk of Breast, Prostate, and Ovarian Cancers." J Natl Cancer Inst 108, no. 2 (Feb 2016).

Ngwa, Wilfred, Twalib Ngoma, Anthony Zietman, Nina Mayr, Ahmed Elzawawy, Thomas A. Winningham, Onyinye Balogun et al. "Closing the cancer divide through ubuntu: information and communication technology-powered models for global radiation oncology." International journal of radiation oncology, biology, physics 94, no. 3 (2016): 440.  

Nielsen, Sarah M., Lindsay Rhodes, Ignacio Blanco, Wendy K. Chung, Charis Eng, Eamonn R. Maher, Stéphane Richard, and Rachel H. Giles. "Von Hippel-Lindau Disease: Genetics and Role of Genetic Counseling in a Multiple Neoplasia Syndrome." Journal of Clinical Oncology (2016): JCO656140.

Nielsen, Sarah M., Michael G. White, Susan Hong, Briseis Aschebrook-Kilfoy, Edwin L. Kaplan, Peter Angelos, Swati A. Kulkarni, Olufunmilayo I. Olopade, and Raymon H. Grogan. "The Breast–Thyroid Cancer Link: A Systematic Review and Meta-analysis." Cancer Epidemiology Biomarkers & Prevention 25, no. 2 (2016): 231-238.

 Polite BN, Cipriano-Steffens T, Hlubocky F, Dignam J, Ray M, Smith D, Undevia S, Sprague E, Olopade O, Daugherty C, Fitchett G, Gehlert S. An Evaluation of Psychosocial and Religious Belief Differences in a Diverse Racial and Socioeconomic Urban Cancer Population. J Racial Ethn Health Disparities 2016.

Rebbeck, T. R., T. M. Friebel, N. Mitra, F. Wan, S. Chen, I. L. Andrulis, P. Apostolou, et al. "Inheritance of Deleterious Mutations at Both Brca1 and Brca2 in an International Sample of 32,295 Women." Breast Cancer Res 18, no. 1 (Nov 11 2016): 112.

Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ, Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ, Investigators IS. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med 2016; 375: 23-34.

Silvestri, V., D. Barrowdale, A. M. Mulligan, S. L. Neuhausen, S. Fox, B. Y. Karlan, G. Mitchell, et al. "Male Breast Cancer in Brca1 and Brca2 Mutation Carriers: Pathology Data from the Consortium of Investigators of Modifiers of Brca1/2." Breast Cancer Res 18, no. 1 (Feb 09 2016): 15.

Stoll, Jessica, Scott M. Weissman, Nicole Hook, Christina Selkirk, Amy Knight Johnson, Anna Newlin, and Kristen J. Vogel Postula. "Evaluation of laboratory perspectives on hereditary cancer panels." Familial Cancer (2016): 1-8.

Xu J, Chen Y, Huo D, Khramtsov A, Khramtsova G, Zhang C, Goss KH, Olopade OI. beta-catenin regulates c-Myc and CDKN1A expression in breast cancer cells. Mol Carcinog 2016; 55: 431-439.

Vasanthakumar A, Arnovitz S, Marquez R, Lepore J, Rafidi G, Asom A, Weatherly M, Davis EM, Neistadt B, Duszynski R, Vardiman JW, Le Beau MM, Godley LA and Churpek JE.  Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.  Blood.  2016 Jan 21;127(3):310-3. PMID: 26644450. 

2015

Baretta, Zora, Olufunmilayo I. Olopade, and Dezheng Huo. "Heterogeneity in hormone-receptor status and survival outcomes among women with synchronous and metachronous bilateral breast cancers." The Breast 24.2 (2015): 131-136.   Bradbury AR, Patrick-Miller L, Long J, Powers J, Stopfer J, Forman A, Rybak C, Mattie K, Brandt A, Chambers R, Chung WK, Churpek J, Daly MB, Digiovanni L, Farengo-Clark D, Fetzer D, Ganschow P, Grana G, Gulden C, Hall M, Kohler L, Maxwell K, Merrill S, Montgomery S, Mueller R, Nielsen S, Olopade O, Rainey K, Seelaus C, Nathanson KL, Domchek SM. Development of a tiered and binned genetic counseling model for informed consent in the era of multiplex testing for cancer susceptibility. Genet Med 2015; 17: 485-492.  

Catenacci, Daniel VT, Andrea L. Amico, Sarah M. Nielsen, Daniel M. Geynisman, Brittany Rambo, George B. Carey, Cassandra Gulden et al. "Tumor genome analysis includes germline genome: Are we ready for surprises?." International Journal of Cancer 136, no. 7 (2015): 1559-1567.

Churpek, Jane E., Tom Walsh, Yonglan Zheng, Zakiya Moton, Anne M. Thornton, Ming K. Lee, Silvia Casadei et al. "Inherited predisposition to breast cancer among African American women." Breast Cancer Research and Treatment 149, no. 1 (2015): 31-39.

Daly, Bobby, and Olufunmilayo I. Olopade. "Race, Ethnicity, and the Diagnosis of Breast Cancer." JAMA 313, no. 2 (2015): 141-142.

Daly, Bobby, and Olufunmilayo I. Olopade. "A perfect storm: How tumor biology, genomics, and health care delivery patterns collide to create a racial survival disparity in breast cancer and proposed interventions for change." CA: A Cancer Journal for Clinicians 65, no. 3 (2015): 221-238.

Guindalini RS, Win AK, Gulden C, Lindor NM, Newcomb PA, Haile RW, Raymond V, Stoffel E, Hall M, Llor X, Ukaegbu CI, Solomon I, Weitzel J, Kalady M, Blanco A, Terdiman J, Shuttlesworth GA, Lynch PM, Hampel H, Lynch HT, Jenkins MA, Olopade OI, Kupfer SS. Mutation spectrum and risk of colorectal cancer in African American families with Lynch syndrome. Gastroenterology 2015; 149: 1446-1453.

Ikeda, Yuji, Kazuma Kiyotani, Poh Yin Yew, Taigo Kato, Kenji Tamura, Kai Lee Yap, Sarah Nielsen et al. "Germline PARP4 mutations in patients with primary thyroid and breast cancers." Endocrine-related cancer (2015): ERC-15.

Kuchenbaecker, K. B., S. J. Ramus, J. Tyrer, A. Lee, H. C. Shen, J. Beesley, K. Lawrenson, et al. "Identification of Six New Susceptibility Loci for Invasive Epithelial Ovarian Cancer." Nat Genet 47, no. 2 (Feb 2015): 164-71.

Metcalfe K, Lynch HT, Foulkes WD, Tung N, Kim-Sing C, Olopade OI, Eisen A, Rosen B, Snyder C, Gershman S, Sun P, Narod SA. Effect of Oophorectomy on Survival After Breast Cancer in BRCA1 and BRCA2 Mutation Carriers. JAMA Oncol 2015; 1: 306-313.

Pruitt, Liese, Tolulope Mumuni, Eugene Raikhel, Adeyinka Ademola, Temidayo Ogundiran, Adeniyi Adenipekun, Imran Morhason-Bello, Oladosu A. Ojengbede, and Olufunmilayo I. Olopade. "Social barriers to diagnosis and treatment of breast cancer in patients presenting at a teaching hospital in Ibadan, Nigeria." Global public health 10, no. 3 (2015): 331-344.  

Rebbeck, T. R., N. Mitra, F. Wan, O. M. Sinilnikova, S. Healey, L. McGuffog, S. Mazoyer, et al. "Association of Type and Location of Brca1 and Brca2 Mutations with Risk of Breast and Ovarian Cancer." JAMA 313, no. 13 (Apr 07 2015): 1347-61.

Sehdev A, Shih YC, Vekhter B, Bissonnette MB, Olopade OI, Polite BN. Metformin for primary colorectal cancer prevention in patients with diabetes: a case-control study in a US population. Cancer 2015; 121: 1071-1078.

Sighoko D, Ogundiran T, Ademola A, Adebamowo C, Chen L, Odedina S, Anetor I, Ndom P, Gakwaya A, Ojengbede O, Huo D, Olopade OI. Breast cancer risk after full-term pregnancies among African women from Nigeria, Cameroon, and Uganda. Cancer 2015; 121: 2237-2243.

2014

Chai, Xinglei, Tara M. Friebel, Christian F. Singer, D. Gareth Evans, Henry T. Lynch, Claudine Isaacs, Judy E. Garber et al. "Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2 mutation carriers." Breast cancer research and treatment 148, no. 2 (2014): 397-406.

Feng Y, Stram DO, Rhie SK, Millikan RC, Ambrosone CB, John EM, Bernstein L, Zheng W, Olshan AF, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Palmer JR, Olopade OI, Huo D, Adebamowo CA, Ogundiran T, Chen GK, Stram A, Park K, Rand KA, Chanock SJ, Le Marchand L, Kolonel LN, Conti DV, Easton D, Henderson BE, Haiman CA. A comprehensive examination of breast cancer risk loci in African American women. Hum Mol Genet 2014; 23: 5518-5526.

Gierach GL, Li H, Loud JT, Greene MH, Chow CK, Lan L, Prindiville SA, Eng-Wong J, Soballe PW, Giambartolomei C, Mai PL, Galbo CE, Nichols K, Calzone KA, Olopade OI, Gail MH, Giger ML. Relationships between computer-extracted mammographic texture pattern features and BRCA1/2 mutation status: a cross-sectional study. Breast Cancer Research 2014; 16: 424.

Gronwald, Jacek, Andre Robidoux, Charmaine Kim-Sing, Nadine Tung, Henry T. Lynch, William D. Foulkes, Siranoush Manoukian et al. "Duration of tamoxifen use and the risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers." Breast cancer research and treatment 146, no. 2 (2014): 421-427.  

Kuchenbaecker, K. B., S. L. Neuhausen, M. Robson, D. Barrowdale, L. McGuffog, A. M. Mulligan, I. L. Andrulis, et al. "Associations of Common Breast Cancer Susceptibility Alleles with Risk of Breast Cancer Subtypes in Brca1 and Brca2 Mutation Carriers." Breast Cancer Res 16, no. 6 (Dec 31 2014): 3416.

Lee RT, Barbo A, Lopez G, Melhem-Bertrandt A, Lin H, Olopade OI, Curlin FA. National survey of US oncologists' knowledge, attitudes, and practice patterns regarding herb and supplement use by patients with cancer. J Clin Oncol 2014; 32: 4095-4101.

Li, Hui, Maryellen L. Giger, Chang Sun, Umnouy Ponsukcharoen, Dezheng Huo, Li Lan, Olufunmilayo I. Olopade, Andrew R. Jamieson, Jeremy Bancroft Brown, and Anna Di Rienzo. "Pilot study demonstrating potential association between breast cancer image‐based risk phenotypes and genomic biomarkers." Medical physics 41, no. 3 (2014).  

Osorio, A., R. L. Milne, K. Kuchenbaecker, T. Vaclova, G. Pita, R. Alonso, P. Peterlongo, et al. "DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in Brca1 and Brca2 Mutation Carriers." [In English]. PLoS Genetics 10, no. 4 (Apr 2014): e1004256.

Qian F, Ogundiran T, Hou N, Ndom P, Gakwaya A, Jombwe J, Morhason-Bello I, Adebamowo C, Ademola A, Ojengbede O, Olopade OI, Huo D. Alcohol consumption and breast cancer risk among women in three sub-Saharan African countries. PLoS ONE 2014; 9: e106908.

2013

Bhatta, Sumita S., Ningqi Hou, Zakiya N. Moton, Blase N. Polite, Gini F. Fleming, Olufunmilayo I. Olopade, Dezheng Huo, and Susan Hong. "Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer." SpringerPlus 2, no. 1 (2013): 356.

Couch, F. J., X. Wang, L. McGuffog, A. Lee, C. Olswold, K. B. Kuchenbaecker, P. Soucy, et al. "Genome-Wide Association Study in Brca1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk." PLoS Genet 9, no. 3 (2013): e1003212.

 Hou N, Hong S, Wang W, Olopade OI, Dignam JJ, Huo D. Hormone replacement therapy and breast cancer: heterogeneous risks by race, weight, and breast density. Journal of the National Cancer Institute 2013; 105: 1365-1372.

Hou N, Ogundiran T, Ojengbede O, Morhason-Bello I, Zheng Y, Fackenthal J, Adebamowo C, Anetor I, Akinleye S, Olopade OI, Huo D. Risk factors for pregnancy-associated breast cancer: a report from the Nigerian Breast Cancer Study. Ann Epidemiol 2013; 23: 551-557.

Monda, K. L., G. K. Chen, K. C. Taylor, C. Palmer, T. L. Edwards, L. A. Lange, M. C. Ng, et al. "A Meta-Analysis Identifies New Loci Associated with Body Mass Index in Individuals of African Ancestry." Nat Genet 45, no. 6 (Jun 2013): 690-6.

Oluwasola, Abideen O., David Malaka, Andrey Ilyich Khramtsov, Offiong Francis Ikpatt, Abayomi Odetunde, Oyinlolu Olorunsogo Adeyanju, Walmy Elisabeth Sveen, Adeyinka Gloria Falusi, Dezheng Huo, and Olufunmilayo Ibironke Olopade. "Use of Web-based training for quality improvement between a field immunohistochemistry laboratory in Nigeria and its United States–based partner institution." Annals of diagnostic pathology 17, no. 6 (2013): 526-530.  

Valentini A, Lubinski J, Byrski T, Ghadirian P, Moller P, Lynch HT, Ainsworth P, Neuhausen SL, Weitzel J, Singer CF, Olopade OI, Saal H, Lyonnet DS, Foulkes WD, Kim-Sing C, Manoukian S, Zakalik D, Armel S, Senter L, Eng C, Grunfeld E, Chiarelli AM, Poll A, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study G. The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation. Breast Cancer Res Treat 2013; 142: 177-185.

Yamaguchi, Ken, David Schacht, Gillian M. Newstead, Angela R. Bradbury, Marion S. Verp, Olufunmilayo I. Olopade, and Hiroyuki Abe. "Breast cancer detected on an incident (second or subsequent) round of screening MRI: MRI features of false-negative cases." American Journal of Roentgenology 201, no. 5 (2013): 1155-1163.

2012

Zheng, Yonglan, Dezheng Huo, Jing Zhang, Toshio F. Yoshimatsu, Qun Niu, and Olufunmilayo I. Olopade. "Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women." PloS one 7, no. 7 (2012): e40494.