Multi Modality Surveillance Program for Women at High Risk for Breast Cancer

Principal Investigator: Olufunmilayo Olopade, M.D.

A Multi Modality Surveillance Program for Women at High Risk for Breast Cancer (protocol 13073B) is a study meant to develop a coordinated, standardized screening program for the early detection of breast cancer in high-risk women. This would include Breast Mammography and Magnetic Resonance Imaging (MRI) examination of your breasts. The University of Chicago Department of Radiology is performing research to develop better ways of imaging the breast, and we would like to be able to reliably identify abnormal tissue and determine whether abnormal areas contain cancer without surgical procedures (i.e. a biopsy which involves removing breast tissue with a needle or surgical instrument).

In young women, dense breasts sometimes make it difficult to find abnormal changes on breast cancer screening (mammograms) . MRI, in combination with mammography, may increase the rate of detection of early cancers. In addition, MRI can provide better images of breast tissue. We hope to prove that combining multiple screening measures including biomarkers improves the chances that, if one has a small cancer or pre-cancer, it will be found early. This study will also evaluate quality of life measures during breast cancer screening and compares breast MRI and mammograms in a high-risk population. We will establish a database of clinical characteristics, blood biomarkers, and interventions that will be saved for future analysis and aid in the development of more effective screening in high-risk women. This research will also help us develop tools for studies in the future. This study began in 2005, and approximately 500 women will be enrolled on this study.